Is there a way to change specific tiles in a tilemap when the game is running when an event happens like when a signal is triggered?

    09kingarthur In godot 3.5 look at the set_cellv() function and it's input parameters. Setting the first parameter to -1 clears the tile. The integer relates to the tiles available in the tilemap in the order they are shown in the inspector when painting tiles in the editor.

      If you right click your TileMap node you can also just hit Open Documentation. You'll often find a function that can do something that's close to what you want.