Pixels are okay if done right. Sheltered used pixels, but given the animations it had, it's a good thing they were. These range from getting sick to answering nature's call. Ewww, I am so glad that was so unrealistic.
Beat Cop uses pixels, though, and the graphics are so lame. PS: it was a game for mature audiences only. Still, it felt like the main thing that made it mature was a swear word thrown in very often. Not the best experience if you just want to play detective.