Capella
I have this setup, but the Camera2D is still affecting my Sprite2Ds. I tried a TextureRect but still got the same results. This is incredibly frustrating 😅

EDIT: I just noticed I had "Follow Viewport" on! Turning it off made the sprites disappear, but the docs say the following so I'm hopeful:
"If enabled, the CanvasLayer will use the viewport's transform, so it will move when camera moves instead of being anchored in a fixed position on the screen."
SOLUTION: Scaled the CanvasLayer down to 0.1 and set the Offset to half my target resolution (full-HD)! Thank you for pointing me in the right direction Capella!